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Refining animal models in fracture research:seeking consensus in optimising both animal welfare and scientific validity for appropriatebiomedical use. Bista M et al (2012) On the mechanism of action of SJ-172550 in inhibiting the interaction ofMDM4 and p53. They account for less than 1%of all epithelial cells in the gastrointestinal tract, but as a whole,they collectively constitute the largest endocrine "organ" in thebody.

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In both prostate and testicular can-cers, tumor markers that are used to follow treatment outcomes createsignificant anxiety. In total, over 40different alternative splice variants have been identi?ed in human tumors, most ofwhich lack the p53-binding domain. Unlike hyperplastic polyps,adenomatous polyps can produce symptoms like epigastricdiscomfort, bleeding, or rarely obstruction (Levine 2008 ).Most adenomatous polyps are larger than 2 cm in size andusually occur as single lesion

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